The biggest crypto gainers of all-time have reshaped the investment landscape, delivering exponential returns that outpaced traditional assets. Coins like Bitcoin (BTC), which surged from mere cents to over $60,000, and Ethereum (ETH), rising from $0.30 to thousands of dollars, are prime examples of crypto's wealth-generating power. Other standout performers include Shiba Inu (SHIB) and Dogecoin (DOGE), which turned early adopters into millionaires during major bull runs.