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Sukarelawan Vaksin Covid-19 Oxford AstraZeneca Alami Gangguan Tulang Belakang
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https://www.kaskus.co.id/thread/5f5984a3dbf76431ce05f4bf/sukarelawan-vaksin-covid-19-oxford-astrazeneca-alami-gangguan-tulang-belakang

Sukarelawan Vaksin Covid-19 Oxford AstraZeneca Alami Gangguan Tulang Belakang

Sukarelawan Vaksin Covid-19 Oxford AstraZeneca Alami Gangguan Tulang Belakang

Bisnis.com, JAKARTA - Sukarelawan atau pasien yang disuntik vaksin uji coba Oxford 'menunjukkan gejala gangguan tulang belakang' yang langka.

Hal tersebut yang membuat AstraZeneca dan Oxford University memutuskan untuk setop sementara pelaksanaan uji klinis, sambil melakukan pemeriksaan.

Kepala Eksekutif AstraZeneca Pascal Soriot mengatakan uji coba vaksin perusahaan dihentikan sementara karena seorang wanita mengalami gejala gangguan tulang belakang. Dia mengonfirmasi hal itu melalui telepon kepada investor.

Menurutnya, bahwa wanita tersebut menunjukkan gejala neurologis dari gangguan inflamasi tulang belakang myelitis transversal, demikian situs web kesehatan Stat melaporkan dikutip dari metro.

Mr Soriot mengatakan wanita yang berasal dari Inggris itu, disuntik dengan vaksin Covid-19 dan bukan plasebo. Dia menambahkan, wanita itu belum secara resmi didiagnosis dengan kondisi masalah tulang belakang, dan diharapkan keluar dari rumah sakit hari ini, katanya.

Kemitraan Oxford-AstraZeneca adalah salah satu uji coba vaksin yang paling diawasi di dunia setelah menunjukkan hasil yang menggembirakan dalam pengujian fase 1 dan fase 2. Uji coba fase 3 telah melibatkan sekitar 30.000 peserta dari Inggris, AS, Brasil, dan Afrika Selatan.

Para ahli mengatakan sering kali ada jeda dalam uji coba vaksin dan reaksi merugikan di antara peserta dipantau secara ketat.

AstraZeneca mengatakan penyelidikan independen akan menentukan apakah kondisi wanita itu terkait dengan vaksinnya. Menurut NHS, myelitis transversal dapat menyebabkan orang kehilangan penglihatan dan mengalami nyeri hebat di lengan atau tungkai. Dikatakan serangan itu bisa sekali atau kambuh.

Dalam percakapannya dengan investor, Soriot juga mengatakan uji klinis ditangguhkan sekali sebelumnya pada bulan Juni setelah pasien mengalami gejala neurologis. Uji coba vaksin juga dihentikan pada bulan Juli.

Bos AstraZeneca mengatakan bahwa peserta kemudian didiagnosis menderita multiple sclerosis, yang tidak terkait dengan vaksin. Salah satu penelepon dilaporkan mengatakan AstraZenca ingin meyakinkan investor bahwa perusahaan menganggap serius hal tersebut.

Menurut Organisasi Kesehatan Dunia, saat ini ada 180 program vaksin virus korona yang sedang dikembangkan di seluruh dunia. Dan hingga kini belum ada yang menyelesaikan uji klinis



sumber : 
https://lifestyle.bisnis.com/read/20...ulang-belakang


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moga vaksin yang akan dipakai di indonesia,
aman dari dampak buruk.

yg sedang diuji coba saat ini di indonesia, kabarnya cukup aman.
paling sakit disuntik dan demam beberapa hari.

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ujellyjello dan 29 lainnya memberi reputasi
Diubah oleh Ribao
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awalnya vaksin oxford digadang2 sbg vaksin kandidat teratas
sementara vaksin cinak trus dihujat dan dicibir

sekarang malah berbalik
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Itu yg ketahuan
Kalo mintanya buru buru gradakan ,bisa jadi ada efek samping impotent massal, baru lu semua kaing kaing emoticon-Ngakak
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Nah lho.. Gimana bisa sekelas oxford miss yg kayak gini?
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Waduhhh
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waduh jadi dah nih zombie apocalypse
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emoticon-Blue Guy Peaceemoticon-Hi

Sebetulnya ini indikator bagus
artinya safety measure saat uji klinis bener2 dijalankan

dugaan ane sih sukarelawan itu sakitnya gak terkait vaksin
cuman ya tentu perlu dikaji dulu secara ilmiah



emoticon-linux2
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Makanya pilih vaksin dari cina..... Lewatin uea, jadi vaksin super hahaha...
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Pemuja bule dan pemuja vaksin bule kok pd mingkem skrg

Kmren kmren pd ngejek vaksin chinaemoticon-Ngakak
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AstraZeneca juga sama2 udah tahap 3 uji klinis...

Pembelajaran : vaksin yg. awalnya diberitakan sangat menjanjikan pun, bisa gagal...

Butuh proses panjang untuk produksi vaksin, tidak bisa dipercepat, dan bahkan dibuat instant...
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Criticism of the Oxford Coronavirus Vaccine

By Derek Lowe 18 May, 2020

This piece at Forbes by Bill Haseltine has set off a lot of comment – it’s a look at the Oxford group’s vaccine candidate as compared to the SinoVac candidate, and you may recall (background here) that these are the two teams that have separately reported that their vaccines appear to protect rhesus monkeys from infection after exposure to the coronavirus. Haseltine has some criticisms of the Oxford data, and as you will see from that link to his name, his opinions deserve to be taken seriously. So what’s going on? Update: here’s the take on this at BioCentury.

Looking at the preprint on the Oxford results, Haseltine has a problem with the claim that the monkeys were protected from infection by a dose of ChAdOx1 nCoV-19. The key data are in the preprint’s Figure 3. The Oxford team checked for viral RNA several different ways. One was using bronchoaveolar lavage (BAL fluid), a sampling technique that involves running a bronchoscope down into the lungs and washing out aveolar spaces – a pretty darn invasive assay, which is why you don’t hear about it all that much compared to the still-not-so-nonivasive nose swabs. BAL fluid of the virus-exposed unvaccinated animals showed coronavirus genomic RNA throughout the study, and viral subgenomic RNA (more indicative of active replication) at days 3 and 5 after exposure. Meanwhile, the vaccinated animals showed the genomic RNA in only two monkeys, and no subgenomic RNA at all.

So far, so good. But both vaccinated and unvaccinated monkeys showed the same amount of viral genomic RNA from nose swab samples (Figure 3c). That’s the test that’s used out in the human population, and that means that the vaccinated animals would still be declared as positive for the coronavirus after being exposed to it. And the other thing that Haseltine notes is that the amount (the “titer”, in the lingo) of neutralizing antibodies in the blood of the vaccinated animals does not appear to be that high. You’d like to be able to dilute the blood antibody samples down by hundreds of times or even a thousandfold and still see antiviral activity in an in vitro assay, but in the Oxford case the activity started disappearing at about fortyfold dilution (Figure 2b).

On the positive side, 2/3 of the unvaccinated animals showed clear evidence of viral pneumonia at autopsy, but none of the vaccinated ones did. The conclusion is that the vaccinated animals were indeed infected – the vaccine did not protect against that – but that the disease was definitely less severe. But these results mean that the virus might well still be transmissible from people who had been so vaccinated, even if the disease course itself was not as deadly. You’d want to do better than that, if you can. Haseltine’s take is “Time will tell if this is the best approach. I wouldn’t bet on it.”

Haseltine compares these results to the SinoVac inactivated virus vaccine, and finds that that one looks better – at its highest dose, no viral RNA was recovered from the tissues of the vaccinated animals, for example. This sort of “sterilizing immunity” is what you’d want to aim for – it gives the virus nowhere to go in the human population if you can vaccinate enough people. But it’s worth noting that the SinoVac results were from three doses of their vaccine (versus one of the Oxford candidate), and the viral exposure challenge was about half as strong (total viral particles) as what the Oxford paper used. The Oxford group also inoculated their monkeys in both the upper and lower respiratory tract, while the SinoVac team used a single inoculation in the trachea. So I agree with that tweet linked from AndyBiotech; I don’t think that a head-to-head comparison is fair. But Haseltine’s point stands, that the results as we have them from the ChAdOx1 nCoV-19 vaccine did not actually protect monkeys from infection.

If you dosed it more than once, perhaps it would. Update: that’s not going to work, of course. After a shot of the adenovirus vector, you’re not only going to have neutralizing antibodies to the desired antigen, but you’re going to have them to the adenovirus as well. It’s probably one shot and done. Update 2: maybe not! See this trial; they’re going to try it and see what happens. But we’re going to have to keep an eye on dosing schedules, of course. We’re looking at a massive effort to vaccinate people all over the world, in the end, and if we have to vaccinate them all twice (at, say, a two-month interval) then the problem becomes just that much harder. Three times, well, that’s something that I think we’re only going to seriously consider if we absolutely have to. If you want to picture an ideal vaccine, it’s one dose, sterilizing immunity, extremely low incidence of side effects. We have no idea at present if we’re going to get that, or even be able to get that, and the only way we’ll find out is human data. Lots and lots of human data. May the best vaccine win, and may the best vaccine be very good indeed. . .

https://blogs.sciencemag.org/pipelin...avirus-vaccine
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Jadi punya cinak yg bagus ya ?

emoticon-Bingung
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Brazil governor says coronavirus vaccine trials promising: Live

Governor of Sao Paulo state says clinical trials of Sinovac COVID-19 vaccine has shown promising results.
by Kate Mayberry, Virginia Pietromarchi & Arwa Ibrahim
3 hours ago

The governor of Brazil's Sao Paulo state said that Phase 3 clinical trials of a potential COVID-19 vaccine developed by China's Sinovac Biotech Ltd have shown promising results and it may be available to Brazilians as early as December.
AstraZeneca says it has suspended trials of the coronavirus vaccine it is developing with the University of Oxford after one of the trials' volunteers fell ill with an unexplained illness.
More than 27.5 million people around the world have been diagnosed with the coronavirus and 900,079 have died. Nearly 18.5 million people have recovered.

https://www.aljazeera.com/news/2020/...232523435.html
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Sukarelawan Vaksin Covid-19 Oxford AstraZeneca Alami Gangguan Tulang Belakang
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soljin7 dan 4 lainnya memberi reputasi
sinovac dari china uda paling bener
gapercaya ?
seiring berjalannya waktu liat aja nanti seluruh dunia bakal pakai vaksin ini
emoticon-Shakehand2
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666fapfap dan 2 lainnya memberi reputasi
Kalo yang punya rusia gimana tuh? Sampe anak'nya putin udah di vaksin
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Rest in peace RK emoticon-Frown
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kalo 1.000.000 orang yg vaksin... 10 kena masalah apapun itu... bukan berarti efek samping dr vaksinnya...

kalo dari yg 1.000.0000 itu yg 100.000 kena masalah.. nah bs jd dari vaksinnya...

butuh investigasi lbh lanjut...
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makanya si erik takut nyuruh rakyat jadi tikus lab buat dia
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haduh.. permnen ga ? pak RK sehat?
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hmm, beda vaksin,

semoga yang chincong lancar emoticon-linux2
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