Neighbors centers on a regular guy (Seth Rogen) and his family who have the bad luck to live next to a college fraternity house. This place of debaucery harbors an especially clamorous member (Zac Efron) who makes their life most miserable.

Filmmaker Nicholas Stoller in the past worked closely with the king of the R-rated comedies, Judd Apatow, having directed the Apatow produced Forgetting Sarah Marshall, Five Year Engagement, and Get Him to the Greek.