Berikut adalah prestasi yang berhasil diraih Messi sepanjang karier sebagai pesepakbola profesional di level Negara, klub, ataupun penghargaan individu:
 
BARCELONA
• Juara La Liga 5 kali
• Juara Copa del Rey 1 kali
• Juara Supercopa de Espana 5 kali
• Juara UEFA Champions League 3 kali
• Juara UEFA Super Cup 2 kali
• Juara FIFA Club World Cup Championship 2 kali
 
ARGENTINA
• FIFA U-20 World Cup 1 kali
• Olympic Gold Medal 1 kali
 
PENGHARGAAN INDIVIDU
• Ballon d’Or 3 kali
• FIFA World Player of the Year 1 kali
• FIFA Team of the Year 1 kali
• U-21 Europan Footballer of the Year 1 kali
• La Liga Player of the Year 3 kali
• La Liga Top Goal Top Scorer 1 kali
• Copa del Rey Top Scorer 1 kali
• La Liga Foreign Player of the Year 3 kali
• La Liga Ibero – American Player of the Year 4 kali
• European Golden Shoe 1 kali
• UEFA Champions League Top Goalscorer 3 kali
• UEFA Best Player in Europe 1 kali
• UEFA Club Footballer of the Year 1 kali
• UEFA Champions League Forward of the Year 1 kali
• UEFA Champions League Final Fans Man of the Match 2 kali
• UEFA Team of the Year 3 kali
• Footballer of the Year of Argentina 5 kali
• FIFPro World Player of the Year 2 kali
• FIFPro World Young Player of the Year 3 kali
• FIFPro Special Young Player of the Year 2 kali
• FIFPro World XI 4 kali
• FIFA U-20 World Cup Player of Tournament 1 kali
• FIFA U-20 World Cup Top Scorer 1 kali
• Copa America Young Player of the Tournament 1 kali
• World Soccer Player of the Year 1 kali
• World Soccer Young Player of the Year 3 kali
• FIFA Club World Cup Golden Ball 1 kali
• ESM Team of the Year 5 kali
• Onze d’Or 2 kali
• Bravo Award 1 kali
• Marca Leyenda 1 kali
• UEFA Best Goal of the Year 1 kali